_1568962753 1568962753 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Mohammed Kassem Othman Al-qadasy Abdulla Saleh Babaqi Mukhtar Mohammed Al-Abyadh Ali Gamal Ahmed Al-kaf This study investigates concentrations of toxic metals, Lead and Cadmium in water, sediments and fish organs (muscle, liver and gill). Collected from Aden coast, gulf of Aden in Yemen. Water samples and sediment were taken from nine locations. Four fish species were collected (Lethrinus mahsena; Epinephelus  areolatus; Thunnus tonggol and  Sphyraena jello) were collected from the local commercial fishermen of Aden city during winter 2011,  Summer 2012 and winter 2013. Lead concentration in sea water is 0.045-0.055 mg/l and Lead concentration in Sediment 33.512-35.726 µg/g dry wt., Cadmium concentration in sea water 0.006-0.010 mg/l, Cadmium concentration in sediment 1.944-2.004 µg/g dry wt., lead concentration is the highest  in most fish gill samples 0.047-0.727 µg/g dry wt., where as in muscles is the lowest 0.020-0.116 µg/g dry wt., and  in liver was 0.038- 0.267 µg/g dry wt. Cadmium concentration is the highest  in most fish gill samples 0.033-0.609 µg/g dry wt., where as in muscles is the lowest 0.018- 0.073 µg/g dry wt., and  in liver was 0.028-0.209 µg/g dry wt. By comparing the results obtained with other data obtained from the local and international studies, in addition to, comparing the results standard levels of these metals contaminated and adopted internationally and domestically and the pollution levels in Yemen is currently within the lower limits of pollution. Google Scholar 11 01 2017 10.22270/ujpr.v2i6.R8 http://ujpr.org/index.php/journal/article/view/105 http://ujpr.org/index.php/journal/article/download/105/81 http://ujpr.org/index.php/journal/article/download/105/263 http://ujpr.org/index.php/journal/article/download/105/81 http://ujpr.org/index.php/journal/article/download/105/263