_1710482620 20240315060340000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 03 15 2024 Nurzadrina Wahyuddin https://orcid.org/0009-0000-8291-820X Yuri Pratiwi Utami https://orcid.org/0009-0001-6871-606X Noer Fauziah Rahman https://orcid.org/0000-0003-3050-7681 Andi Rainun Puspa Nodjeng https://orcid.org/0009-0000-2291-9622 Kezya Ratu Marewa https://orcid.org/0009-0000-4921-4374 Background and aim: Radish tuber (Raphanus sativus L.) is one of the plant species often consumed by society as a vegetable. Currently, its use is beginning to expand as a medicinal plant, including its use for diabetes, pharyngitis, sinusitis, cardiac fibrosis, diuretics, and bacterial infections. This study aims to determine the histopathology of the liver and kidney organs in male albino mice (Mus musculus) by testing the oral pungency of white radish (Raphanus sativus L.). Methods: This experimental study used 12 mice weighing 25–30 grams, divided into 4 treatment groups: Group 1 was administered aquadest, Group 2 received a dose of 400 mg, Group 3 received 800 mg, and Group 4 received 1600 mg of the medication. The treatment was carried out for 14 days, and then the mice were euthanized to see the histopathology of the hepatic and kidney tissues. Results: In the histopathology of the liver and kidney in treatment groups 1, 2, 3, and 4, the results were normal, mild, moderate, and severe damage, respectively. In kidney histopathology, there are signs of damaged tissue, such as bleeding, edema, and inflamation cells. Conclusion: It can be concluded that the higher the dose of white radish lyophilizate, the greater the potential to cause toxicity to the liver and kidney organs.                       Peer Review History: Received 3 December 2023;   Revised 29 January 2024; Accepted 27 February; Available online 15 March 2024 Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewers: Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com 03 15 2024 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v9i1.1058 https://www.ujpr.org/index.php/journal/article/view/1058 https://www.ujpr.org/index.php/journal/article/download/1058/1556 https://www.ujpr.org/index.php/journal/article/download/1058/1556 https://www.ujpr.org/index.php/journal/article/download/1058/1565 https://www.ujpr.org/index.php/journal/article/download/1058/1576