_1568962807 1568962807 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Mohammed Kassem Othman Al-qadasy Abdulla Saleh Babaqi Mukhtar Mohammed Al-Abyadh Ali Gamal Ahmed Al-kaf The present work has been done considering the constant spread pollution of heavy metals in water bodies. Pollution among water bodies is a major global problem. This contaminates not only the water but also the sediment and aquatic life such as fish. The water samples were collected from the Three different Cities of Yemeni coasts. Aden, Al-Hodeidah and AL-Mukalla were chosen for the sample collection. The study was carried out in the all three seasons of winter 2011,  summer 2012 and winter 2013  in order to check seasonal variation of heavy metal pollution.Total 81  samples of each Water were analyzed. The four heavy metals lead, Cadmium, Mercury and arsenic which are considered highly toxic were detected in the samples in the year 2010, 2012 and 2013. The heavy metal concentrations in the samples were measured using the Atomic Absorption Spectrophotometer. The obtained  results showed that the concentration (mg/l) of  the heavy metal in seawater (Pb-0.061±0.005, Cd-0.007±0.001, Hg-0.007±0.0005 and As-0.008±0.0003) mg/l. The obtained results showed that the heavy metals concentrations were significantly higher, during the summer season for seawater samples in all stations during the study period. Because of the frequent use of water in the hot summer, resulting in an increase in sewage, as well as to the high rate of environmental variables in the summer. By comparing the results obtained with other data obtained from the local and international studies, in addition to, comparing the results standard levels of these metals contaminated and adopted internationally and domestically and the pollution levels in Yemen is currently within the lower limits of pollution. However, the study recommends continuing the study of these pollutants and other contaminants and their impact on the environment and marine life especially invertebrates. 11 01 2017 10.22270/ujpr.v2i6.R10 http://ujpr.org/index.php/journal/article/view/107 http://ujpr.org/index.php/journal/article/download/107/83 http://ujpr.org/index.php/journal/article/download/107/265 http://ujpr.org/index.php/journal/article/download/107/83 http://ujpr.org/index.php/journal/article/download/107/265