_1568962859 1568962859 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Mohammed Kassem Othman Al-qadasy Abdulla Saleh Babaqi Mukhtar Mohammed Al-Abyadh Ali Gamal Ahmed Al-kaf The fish samples were collected from the three different Cities of Yemeni coasts. Aden, Al-Hodeidah and AL-Mukalla were chosen for the sample collection. Lethrinusmahsena, Thunnustonggol, Sphyraenajello and Epinephelusareolatus fish samples were considered for the study as they are more common eatable fish among the population.The study was carried out in the all three seasons of winter 2011,  summer 2012 and winter 2013  in order to check seasonal variation of heavy metal pollution.Total  Fish (108 samples of each muscles, liver and gills) were analyzed. The four heavy metals lead, Cadmium, Mercury and arsenic which are considered highly toxic were detected in the samples in the year 2010, 2012 and 2013. The mean concentration of Pb, Cd, Hg and as in muscle was 0.101±0.012, 0.046±0.010, 0.058±0.002 and 0.089±0.002 µg.g-1 dry wt. respectively; whereas in liver was 0.196±0.033, 0.132±0.020, 0.102±0.007 and 0.115±0.0005 µg.g-1 dry wt. respectively; whereas in gill was 0.294±0.042, 0.196±0.063, 0.016±0.0006 and 0.034±0.0005 µg.g-1 dry wt. respectively. The  results showed that, the heavy metals concentrations were high in stations AL- Hudaydah  and AL- Mukalla and low in station of Aden. Also the heavy metals concentrations were high in Seasons summer and low in Seasons winter. From the heavy metal concentrations mentioned above we can see that somewhere the concentration is crossing the limits as permissible by the World Health Organization. It suggests a high risk to the health of human being on the consumption of contaminated fish. Therefore it is recommended that the practice of trace element detection should be continued in order to update whether the heavy metal concentration is above or below the permissible limits and if it is above the limit then precautions must be taken to avoid possible consumption of contaminated eatables. 11 01 2017 10.22270/ujpr.v2i6.R11 http://ujpr.org/index.php/journal/article/view/108 http://ujpr.org/index.php/journal/article/download/108/84 http://ujpr.org/index.php/journal/article/download/108/266 http://ujpr.org/index.php/journal/article/download/108/84 http://ujpr.org/index.php/journal/article/download/108/266