_1731652603 20241115063643000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 11 15 2024 Mostafa Essam Eissa https://orcid.org/0000-0003-3562-5935 This review highlights the multifaceted landscape of metabolic disorders, focusing on often overlooked or understudied conditions. These disorders were categorized based on potential etiology, including rare inherited, disorders of unknown origin, emerging conditions and those influenced by other diseases, environmental factors, or immune dysfunction. Additionally, we explore the impact of personalized metabolic variations and the intricate relationship between metabolism and mental health. By exploring specific examples such as maple syrup urine disease, non-alcoholic fatty liver disease, bile acid malabsorption and mitochondrial disorders, we emphasize the diverse spectrum of metabolic challenges. This overview underscores the need for continued research to unravel the complexities of these conditions, leading to improved diagnosis, treatment and prevention strategies. This is an interesting area for pharmaceutical field that need attention and extensive research to find promising treatments for the underestimated populations impacted by these diseases.                   Peer Review History: Received 22 July 2024;   Reviewed 17 September 2024; Accepted 19 October; Available online 15 November 2024 Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Md. Shahidul Islam, USTC, Chittagong, Bangladesh, S_i_liton@yahoo.com Dr. Mohammad Tauseef, Department of Pharmaceutical Sciences, College of Pharmacy, Chicago State University, mtauseef@csu.edu 11 15 2024 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v9i5.1201 https://ujpronline.com/index.php/journal/article/view/1201 https://ujpronline.com/index.php/journal/article/download/1201/1715 https://ujpronline.com/index.php/journal/article/download/1201/1715 https://ujpronline.com/index.php/journal/article/download/1201/1727 https://ujpronline.com/index.php/journal/article/download/1201/1744