_1736915802 20250115043642000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 01 15 2025 Faradiba Rezki Amriati Syarif https://orcid.org/0009-0000-9900-0681 Anggi Anggrayni https://orcid.org/0009-0002-7196-7131 Elyana Praditha https://orcid.org/0009-0001-8860-4401 Alifiya Reski Amalia https://orcid.org/0009-0008-0635-1334 Aim and objective: This study to determine the antioxidant activity of the combination of ginger (Zingiber officinale) and lemongrass (Cymbopogon citratus) on reducing DPPH (2,2-diphenyl-1-picrylhydrazyl). Methods: Quantitative measurement of the antioxidant activity of ginger and lemongrass extracts, as well as a combination of both with a concentration ratio of 1:1, 2:1, 1:2 using a UV-Vis spectrophotometer at a wavelength of 516 nm to determine the IC50 value. Results: IC50 value of ginger extract 10.76 µg/mL, lemongrass extract 26.69 µg/mL, IC50 value 6.69 µg/mL for combination with concentration ratio 1:1, IC50 value 3.32 µg/mL for combination with concentration ratio 2:1. IC50 value 9.34 µg/mL for combination with concentration ratio 1:2 Conclusions: The combination of ginger and lemongrass extracts has synergistic antioxidant activity that can increase the antioxidant effect from the strong category to very strong category.                     Peer Review History: Received 17 October 2024;   Reviewed 9 November; Accepted 18 December; Available online 15 January 2025 Academic Editor: Dr. Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, ahmad.najib@umi.ac.id Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 01 15 2025 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v9i6.1232 https://ujpronline.com/index.php/journal/article/view/1232 https://ujpronline.com/index.php/journal/article/download/1232/1757 https://ujpronline.com/index.php/journal/article/download/1232/1757 https://ujpronline.com/index.php/journal/article/download/1232/1770 https://ujpronline.com/index.php/journal/article/download/1232/1785