_1736921115 20250115060515000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 01 15 2025 Omar N. Meftah https://orcid.org/0009-0004-1801-0271 Ahshan Ali https://orcid.org/0009-0001-8110-6266 Ali G. Al-kaf This review article offers A brief overview of the most current advancements in synthesis methods and with regard to the pharmacological effects of quinazolinone derivatives. A heterocyclic hybrid quinazolinone having the chemical formula C8H6N2O. It is composed of rings that have been fused together i.e benzene and pyrimidine. The production of quinazolinone derivatives can be accomplished using a variety of methods, such as the Aza-diels-alder reaction, Aza-witting reaction, reaction aided by microwaves, metal-mediated synthesis, palladium-catalyzed reaction, copper-catalyzed reaction, ultrasound-promoted reaction, oxidative cyclization, reagent refluxing, one-pot synthesis, and aqueous media. This review paper included a wide spectrum of pharmacological activities, including a wide range of antibacterial, anti-inflammatory, and analgesic properties of quinazolinone derivatives as well as anti-cancer and anti-oxidant properties were covered in this study.                     Peer Review History: Received 15 October 2024;   Reviewed 7 November; Accepted 21 December; Available online 15 January 2025 Academic Editor: Dr. Iman Muhammad Higazy, National Research Center, Egypt, imane.higazy@hotmail.com Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 01 15 2025 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v9i6.1241 https://ujpronline.com/index.php/journal/article/view/1241 https://ujpronline.com/index.php/journal/article/download/1241/1766 https://ujpronline.com/index.php/journal/article/download/1241/1766 https://ujpronline.com/index.php/journal/article/download/1241/1779 https://ujpronline.com/index.php/journal/article/download/1241/1795