_1736920678 20250115055758000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 01 15 2025 Sukmawati A. Muflihunna Background: Qutsh al Hindi (Saussurea lappa), commonly known as Indian wood, is a traditional medicine that had been used empirically as anti-inflammatory and pneumonia. Its potential as anti-inflammatory activity is proven by many researches in vitro and in vivo. Aim and objective: This study aims to identifying active compounds from the ethyl acetate fraction of Qutsh al Hindi (S. lappa) using GC-MS. Method: The extract was obtained by powder of S. lappa roots using maceration method and evaporated to obtained thick extract. Then, the isolate of extract would be fractionated using n-hexane and ethyl acetate. The compounds that carried out by fractionation would be identified using GC-MS. Result: Based on this research, the analysis of S. lappa ethyl acetate fraction showed 119 compounds using GC-MS. Other supporting factors using Mass Chromatography. The result was one of target compound identified, i.e. β-cyclocostunolide, a derivate compound from costunolide that has an anti-inflammatory activity. Conclusion: It can be concluded that a fraction of S. lappa roots ethyl acetate contain β-cyclocostunolide as anti-inflammatory compounds.                   Peer Review History: Received 11 September 2024;   Reviewed 12 November; Accepted 25 December; Available online 15 January 2025 Academic Editor: Dr. Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, ahmad.najib@umi.ac.id Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 01 15 2025 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v9i6.1245 https://ujpronline.com/index.php/journal/article/view/1245 https://ujpronline.com/index.php/journal/article/download/1245/1783 https://ujpronline.com/index.php/journal/article/download/1245/1783 https://ujpronline.com/index.php/journal/article/download/1245/1784 https://ujpronline.com/index.php/journal/article/download/1245/1791