_1736921162 20250115060602000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 01 15 2025 REVIEW ON CELLULAR SIGNALING, GROWTH FACTORS, AND MECHANICAL STIMULUS IN NERVE REGENERATION Ezegbe Chekwube Andrew Amarachi Grace Ezegbe The nervous system consists of the autonomous and peripheral. Injury on the peripheral nerve which occurs due to trauma, accident and other associated factors always results in a huge loss of both the motor and sensory functions. The injured nerves can be successfully restored although it requires a lot of molecular response in order to rebuild the functional axons. When this is achieved, the damaged nerve can accurately connect with their original targets. The complete recovery of PNI has not been optimized. Exogenous growth factors (GFs) are a new therapeutic strategy that can be used in nerve regeneration. The mechanism of action of growth factor is based on the ability to activate the signaling cascades via binding to the individual receptors in order to exert the multiple effects and restore the neuron and tissue regeneration. Although the GFs are limited by their short half-life and rapid deactivation. The use of nerve conduits has been able to reduce these limitations. The nerve conduits have been good biocompatibility and biofunctionality properties.                    Peer Review History: Received 14 September 2024;   Reviewed 18 November 2024; Accepted 23 December; Available online 15 January 2025 Academic Editor: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, drmmziqbal@gmail.com Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 01 15 2025 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v9i6.1246 https://ujpronline.com/index.php/journal/article/view/1246 https://ujpronline.com/index.php/journal/article/download/1246/1799 https://ujpronline.com/index.php/journal/article/download/1246/1799 https://ujpronline.com/index.php/journal/article/download/1246/1800 https://ujpronline.com/index.php/journal/article/download/1246/1801