_1742026201 20250315081001000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 03 15 2025 Minahil Fatima Eman Ali Aimen Shafqat Muhammad Talha Tariq Laiba Gulraiz Fatima Imran Nadeem Hussain Jannat Awais Namra Rasheed Muhammad Abid Mustafa SARS-CoV-2 was the virus responsible for the COVID-19 pandemic that emerged in 2019. To date, over 670 million individuals have received mRNA-based COVID-19 vaccines. However, emerging evidence suggests a potential association between these vaccines and cardiovascular complications. Concerns have been raised regarding their possible contribution to underrecognized cardiovascular issues, such as arrhythmias and arterial hypertension. The individuals with pre-existing heart conditions are at a higher risk of adverse cardiovascular events and unfavorable clinical outcomes following vaccination. Reported complications include myocarditis, arrhythmias, acute coronary syndromes, heart failure, and thromboembolic events. This review discusses the underlying mechanisms, diagnostic techniques, strategies for treatment, and current limitations of the literature on the possible link between mRNA COVID-19 vaccinations and cardiovascular problems.                   Peer Review History: Received 4 December 2024;   Reviewed 14 January 2025; Accepted 18 February; Available online 15 March 2025 Academic Editor: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com 03 15 2025 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v10i1.1277 https://ujpronline.com/index.php/journal/article/view/1277 https://ujpronline.com/index.php/journal/article/download/1277/1813 https://ujpronline.com/index.php/journal/article/download/1277/1813 https://ujpronline.com/index.php/journal/article/download/1277/1826 https://ujpronline.com/index.php/journal/article/download/1277/1839