_1757918303 20250915063823000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 09 15 2025 Mohammed Yahya Mohammed Jahaf Yahya Abdullah Ahmed Alhadi Hassan Abdulwahab Al-Shamahy Background and aim: Dystonia is a neurological movement disorder characterized by sustained or periodic muscle contractions, resulting in abnormal, often repetitive, body movements or postures, or both. The movements are typically stereotyped and twisting, and may resemble a tremor. This study was conducted to investigate the effectiveness of a modified occlusal splint (the AL Hadi Modified Occlusal Splint) in the treatment of oromandibular dystonia (OMD).   Methodology: Modified Al-Hadi occlusal splints were fitted to 25 patients (21 males and 4 females) with oromandibular dystonia (OMD) and uncontrolled lateral mandibular deviation. These patients underwent monthly follow-ups for six months. The effectiveness of the modified occlusal splint was assessed by measuring changes in speech, pain, discomfort, involuntary lateral jaw movement, and mastication ability. Scores for each symptom ranged from 0 to 4, with a higher score indicating severe impairment. Result: The results showed significant improvement in chewing ability starting from the second visit, as well as significant improvement in speech and discomfort (involuntary lateral jaw movement). However, no significant improvement was observed in pain levels. For example, at the six-month follow-up, 8% of patients reported normal chewing ability, 68% could eat anything without significant time-consuming, and 24% could only eat soft foods. Furthermore, no patient found it difficult or time-consuming to eat only soft foods or liquids. Furthermore, 16% of patients reported normal comfort, and no patient reported severe discomfort. Conclusion: The modified occlusal splint has promise improvement in speech, mastication ability and uncontrolled lateral jaw movement.                       Peer Review History: Received 6 June 2025;   Reviewed 12 July 2025; Accepted 22 August; Available online 15 September 2025 Academic Editor: Dr. Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, ahmad.najib@umi.ac.id Reviewers: Ahmed Tagelsir Mohamed Ali, National University, Sudan, ahmedtagelsir7@hotmail.com Antonio José de Jesus Evangelista, Federal University of Ceará, UFC, Brazil, tony_biomed@hotmail.com 09 15 2025 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v10i4.1386 https://ujpronline.com/index.php/journal/article/view/1386 https://ujpronline.com/index.php/journal/article/download/1386/1937 https://ujpronline.com/index.php/journal/article/download/1386/1937 https://ujpronline.com/index.php/journal/article/download/1386/1951 https://ujpronline.com/index.php/journal/article/download/1386/1967