_1763201698 20251115101458000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 11 15 2025 Ammar Abdullah Al-Kebsi Lutf Mohammed Al-Rahbi Mohammed Hasan mohammed Al-Shoaibi Hassan Abdulwahab Al-Shamahy Background and aims: The symmetrical shape of the nasolabial folds and both nose alae, along with a natural-looking philtrum and Cupid's bow in both static and dynamic phases, as well as a buried scar, are characteristics of the perfect lip restoration. The study's goal was to evaluate the Millard rotational advancement technique and the Fisher anatomical subunit approximation technique for unilateral cleft lip repair. Methods: Prospective study for 30 patients submitted to Palestine Hospital in Sana’a City, Yemen, with unilateral cleft lip deformity between December 2022 and August 2024. The Millard rotational-advancement approach was used to correct fifteen patients with unilateral cleft lip deformity, while the Fisher anatomical subunit approximation technique was used to fix the remaining fifteen. NIH ImageJ software was used to evaluate the patients' postoperative photos using the Steffensen grading criteria. The normal side and the corrected side were compared in terms of lip length, cutaneous line symmetry, vermillion symmetry, scar appearance, Cupid's bow, nostril symmetry, and alar base. Results: A study involving 69.2% males and 38.8% females aged 5-180  months with 30 unilateral cleft lips undergoing Millard and Fisher techniques found that patients with Millard techniques showed better cutaneous line symmetry, vermillion symmetry, and lip length compared to Fisher techniques. However, only 7.7% of patients with Millard procedures showed good Cupid's bow, scar appearance, nasal symmetry, and alar base compared to Fisher techniques. The study suggests that Millard techniques may be more effective in certain cases. Conclusion: In conclusion, there was no discernible change in the anthropometric measurements between the two methods used for unilateral cleft lip repair. According to the study, there are several situations in which applying Millard approaches might be more successful.                     Peer Review History: Received 7 August 2025;   Reviewed 11 September 2025; Accepted 20 October; Available online 15 November 2025 Academic Editor: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, gehankandeel9@yahoo.com  Reviewers: Dr. Sheikh Abdul Khaliq, Department of Pharmacy Practice, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan, drwadhsheikh1974@gmail.com Dr. Taiwo O Elufioye, University of Ibadan, Nigeria, toonitaiwo@yahoo.com 11 15 2025 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v10i5.1425 https://ujpronline.com/index.php/journal/article/view/1425 https://ujpronline.com/index.php/journal/article/download/1425/1991 https://ujpronline.com/index.php/journal/article/download/1425/1991 https://ujpronline.com/index.php/journal/article/download/1425/2004 https://ujpronline.com/index.php/journal/article/download/1425/2019