_1763201792 20251115101632000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 11 15 2025 THE CONVERGENCE OF STATISTICAL PROCESS CONTROL AND QUANTITATIVE MICROBIAL RISK ASSESSMENT: ENHANCING PHARMACEUTICAL QUALITY AND PUBLIC HEALTH SAFETY Mostafa EssamEissa Statistical process control (SPC) has become an essential tool for maintaining quality and safety in pharmaceuticals, public health, and other industries. This review critically examines the applications and synergistic potential of SPC applications in pharmaceutical manufacturing and public health risk assessment. The article demonstrates SPC's effectiveness in monitoring microbiological quality, detecting process variations, and assessing public health risks. Key applications include microbiological quality control of pharmaceutical products and water systems, statistical analysis of disinfectant efficacy, and risk assessment for infectious disease outbreaks. SPC can provide a unified analytical framework, facilitates proactive risk management, and supports data-driven decision-making. Future research should focus on developing standardized SPC protocols, integrating SPC with other data analysis tools, and exploring new applications. SPC enables researchers and practitioners to improve pharmaceutical quality and public health outcomes significantly.                     Peer Review History: Received 2 August 2025;   Reviewed 11 September 2025; Accepted 17 October; Available online 15 November 2025 Academic Editor: Dr. Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, ahmad.najib@umi.ac.id Reviewers: Dr. Heba M. Abd El-Azim, Damanhour University, Egypt, h_m_abdelazim@hotmail.com Dr. Kingsley C Anukam, University of Benin, Nigeria, kanukam@gmail.com 11 15 2025 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v10i5.1428 https://ujpronline.com/index.php/journal/article/view/1428 https://ujpronline.com/index.php/journal/article/download/1428/1994 https://ujpronline.com/index.php/journal/article/download/1428/1994 https://ujpronline.com/index.php/journal/article/download/1428/2007 https://ujpronline.com/index.php/journal/article/download/1428/2023