_1763201866 20251115101746000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 11 15 2025 Emmanuel Ifeanyi Obeagu Iron, an essential micronutrient, serves multiple functions in the development of Human Immunodeficiency Virus (HIV) infection, affecting viral replication, immune responses, and the advancement of the disease. This analysis explores the detailed molecular dynamics of iron management in HIV infection, illuminating the intricate relationship between iron metabolism and viral development. This review investigates the molecular mechanisms related to iron dysregulation in individuals with HIV, clarifying the effects of disrupted iron homeostasis on disease advancement and pinpointing possible therapeutic targets. Iron balance is closely controlled in the body, with disturbances linked to the development of several diseases, such as HIV infection. HIV affects iron metabolism in various ways, impacting both host and viral functions. Iron accumulation, frequently seen in individuals infected with HIV, has been linked to faster disease progression, immune impairment, and higher mortality rates. On the other hand, a lack of iron can weaken immune response and worsen complications related to HIV. Changes in iron balance significantly impact the progression of HIV and its clinical results. Iron imbalance can promote viral reproduction, worsen immune dysfunction, and intensify HIV-related comorbidities such as heart disease, cognitive decline, and anemia. Moreover, oxidative stress and inflammation triggered by iron lead to tissue harm and systemic issues, which further worsen HIV pathogenesis. Clarifying the molecular dynamics of iron orchestration in HIV infection offers important insights into disease mechanisms and reveals possible targets for therapeutic intervention.                   Peer Review History: Received 4 August 2025;   Reviewed 11 September 2025; Accepted 20 October; Available online 15 November 2025 Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com Reviewers:  Dr. Mahmoud S. Abdallah, University of Sadat city, Egypt, dr_samy777@yahoo.com Dr. Mohamed Salama, Modern University for Technology & Information, Egypt, salama47@yahoo.com 11 15 2025 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v10i5.1431 https://ujpronline.com/index.php/journal/article/view/1431 https://ujpronline.com/index.php/journal/article/download/1431/1997 https://ujpronline.com/index.php/journal/article/download/1431/1997 https://ujpronline.com/index.php/journal/article/download/1431/2010 https://ujpronline.com/index.php/journal/article/download/1431/2026