_1768457954 20260115061914000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 01 15 2026 Lutf Mohammed Al-Rahbi Abdulrahman Ali Abdulrahman Abdulsattar Hassan Abdulwahab Al-Shamahy Ahmed Abdulah Al-Ashwal Background and Aims: Bone grafting from the anterior iliac crest is a common and effective method for reconstructing large mandibular defects, as it provides a good source of cortical and cancellous bone. The anterior iliac crest is a preferred donor site due to the large amount of bone available, its anatomical similarity to the mandible, and the possibility of performing a two-team procedure, which reduces overall surgical time. However, potential complications at the donor site include pain, sensory changes, and gait disturbance. This study aimed to evaluate data from 11 patients undergoing mandibular reconstruction using the NVBG technique at our center. Materials and Methods: There were eleven individuals with mandibular reconstruction. Continuity defect and non-continuity defect patients were separated. Factors influencing success were examined, including immediate repair, smoking habit, medical comorbidities, defect site and size, surgical technique, and use of maxilla-mandibular fixation. Success was defined as the preservation of the bone graft for non-continuity defects (NCD) and the continuity and stability of the bone for continuity defects (CD), as well as the absence of infection at the most recent clinical and radiographic assessment. There were two categories for complications: minor and significant. Results: Reconstruction was successful in 12 procedures out of 13 procedures. Analyses showed that the size of the defect was strongly associated with failure. Three patients experienced major complications such as bacterial infection and non-union, and eight experienced minor complications. Conclusion: Non-vascularized iliac crest bone grafts achieve high success in restoring continuity of the mandible in fractures caused by gunshots, bomb  explosions and should be considered the first choice for defects less than 6 cm in diameter. No defects larger than 5.5 cm were recorded in current study.                   Peer Review History: Received 1 October 2025;   Reviewed 5 November 2025; Accepted  11 December; Available online 15 January 2026 Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com Reviewers: Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg Dr. Vanina Doris Edo’o, University of Yaounde I, Yaounde, Cameroun, vanina_edoo@yahoo.com 01 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v10i6.1458 https://ujpronline.com/index.php/journal/article/view/1458 https://ujpronline.com/index.php/journal/article/download/1458/2036 https://ujpronline.com/index.php/journal/article/download/1458/2036 https://ujpronline.com/index.php/journal/article/download/1458/2037 https://ujpronline.com/index.php/journal/article/download/1458/2062