_1768458173 20260115062253000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 01 15 2026 Emmanuel Ifeanyi Obeagu Chukwuma J. Okafor The simultaneous presence of HIV infection and sickle cell disease (SCD) poses considerable immunological and treatment difficulties, especially in areas where both conditions are very common. HIV leads to gradual immunodeficiency by depleting CD4+ T cells and causing chronic immune activation, whereas SCD is marked by ongoing inflammation, hemolysis, and weakened immune responses. These factors together result in a complicated immune environment characterized by increased inflammation, immune fatigue, and greater vulnerability to infections. This review examines the shared immune dysregulation in HIV and SCD, emphasizing the contributions of monocyte activation, T cell impairment, and endothelial damage in promoting disease complications. We examine how persistent inflammation and immune response worsen vaso-occlusive crises, coagulopathy, and blood-related issues, making clinical management more complex. Moreover, the effects of standard therapies including antiretroviral treatment and SCD-specific therapies like hydroxyurea and transfusions on immune balance are evaluated, emphasizing possible drug interactions and immune effects.                     Peer Review History: Received 6 October 2025;   Reviewed 12 November 2025; Accepted  22 December; Available online 15 January 2026 Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr Reviewers: Dr. Nkechi Obiofu Ezenobi, University of Port Harcourt, Nigeria, nkechi.ezenobi@uniport.edu.ng Dr. Nagalingam Varnakulenthiren, Siddha Medicine, Unit of Siddha Medicine, Trincomalee Campus, EUSL, Sri Lanka, drvarnan@gmail.com 01 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v10i6.1466 https://ujpronline.com/index.php/journal/article/view/1466 https://ujpronline.com/index.php/journal/article/download/1466/2052 https://ujpronline.com/index.php/journal/article/download/1466/2052 https://ujpronline.com/index.php/journal/article/download/1466/2053 https://ujpronline.com/index.php/journal/article/download/1466/2070