_1768458195 20260115062315000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 01 15 2026 Said Salim Said Burhani Simai Ahmad Makame Mwadini Sabra Salim Rashid Drug-induced baroreceptor dysfunction represents an underrecognized mechanism contributing to cardiovascular adverse drug reactions, including reflex tachycardia, bradycardia, syncope, orthostatic hypotension, and arrhythmias. However, despite the critical role played by the baroreflex arc in short-term blood pressure regulation through rapid autonomic adjustments, pharmacological impairment of this reflex has not been systematically evaluated in pharmacovigilance systems. This review synthesizes the current evidence on drug-induced baroreceptor dysfunction, discusses the limitations of spontaneous reporting databases, identifies potential pharmacovigilance signal detection methods, and points out major gaps in current knowledge. It also discusses opportunities opened by emerging tools, such as digital health technologies, computational modelling, and real-world evidence to strengthen the early detection of baroreflex related cardiovascular ADRs. We conclude that integrating baroreceptor-specific endpoints into pharmacovigilance frameworks might improve the prediction, detection, and prevention of serious cardiovascular drug reactions.                     Peer Review History: Received 8 October 2025;   Reviewed 11 November 2025; Accepted  20 December; Available online 15 January 2026 Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com Reviewers: Dr. Nada Farrag, Misr International University, Egypt, Nada_Hazem87@hotmail.com Dr. Mujde Eryilmaz, Ankara University,Turkey, meryilmaz@ankara.edu.tr 01 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v10i6.1467 https://ujpronline.com/index.php/journal/article/view/1467 https://ujpronline.com/index.php/journal/article/download/1467/2054 https://ujpronline.com/index.php/journal/article/download/1467/2054 https://ujpronline.com/index.php/journal/article/download/1467/2055 https://ujpronline.com/index.php/journal/article/download/1467/2071