_1778830039 20260515072719000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 05 15 2026 Celse Kwitonda Sonam Choki Kule Gift Diadone Background: Selexipag is an oral, non-prostanoid IP receptor agonist used in treating pulmonary arterial hypertension (PAH). Selexipag has poor aqueous solubility, especially in acidic solution medium. Hence, for the purposes of overcoming solubility limitations associated with selexipag, various techniques such as complexation with appropriate complexing agents have been considered. Cyclodextrins are unique molecules that are cyclic carbohydrates that have been shown to be suitable for the purpose of inclusion complex formation. This is because they form inclusion complexes when combined with insoluble drugs. Method: The inclusion complex between Selexipag and β-cyclodextrin was prepared using kneading method. Result: The ability of β-cyclodextrin to increase the solubility of Selexipag has been shown from the results indicating that β-cyclodextrin improves significantly both the solubility and dissolution of selexipag which is a poorly soluble drug. The formation of the inclusion complex was further confirmed using UV-visible spectrophotometry and Fourier transform infrared spectroscopy. In addition, dissolution studies indicated improved dissolution behavior of the complexed drug. Conclusion: From the results obtained above, β-cyclodextrin appears to be very efficient carrier agent for poorly soluble drugs such as Selexipag which belong to BCS class II.                   Peer Review History: Received 22 February 2026;   Reviewed 9 March 2026; Accepted  17 April; Available online 15 May 2026 Academic Editor: Dr. Ali Abdullah Al-yahawi, Al-Razi university, Department of Pharmacy, Yemen, alyahawipharm@yahoo.com Reviewers: Dr. Mrinal Kanti Bhoumik, Jubilant Cadista Pharmaceutical Inc., mrinal_bhoumik@yahoo.com  Dr. Ahmed Tagelsir Mohamed Ali, National University, Sudan, ahmedtagelsir7@hotmail.com 05 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v11i2.1529 https://ujpronline.com/index.php/journal/article/view/1529 https://ujpronline.com/index.php/journal/article/download/1529/2121 https://ujpronline.com/index.php/journal/article/download/1529/2121 https://ujpronline.com/index.php/journal/article/download/1529/2122 https://ujpronline.com/index.php/journal/article/download/1529/2148