_1784110995 20260715102315000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 07 15 2026 Seerat Shahzad Ayesha Afzaal Rida Afzaal Asma Ashraf Hafiz Muhammad Bilal Syed Hamid Hussain Zaidi Abdul Rehman Abid Zarfshan Shahzad Background: Artificial Intelligence (AI) is increasingly being used in the medicine administration and drug–drug interaction (DDI) screening domain in healthcare. However, its reliability in comparison with the pharmacist review is unknown. This systematic review aimed to compare the effectiveness of DDI alerts generated by AI to DDI alerts generated by pharmacists. Methodology: This review was done in accordance with PRISMA 2020 guidelines and registered with PROSPERO (CRD420251153581). The publications since 2022 were obtained from PubMed, Embase, Scopus, Web of Science, Cochrane Library, IEEE Xplore, and arXiv. The Mixed Methods Appraisal Tool (MMAT) 2018 was used to evaluate the quality of the studies. Results: Fourteen studies of AI systems like ChatGPT, Gemini, Bing AI, and Claude were selected. AI models performed well in general drug information retrieval and were found to have significant shortcomings when it comes to clinical DDI screening. Low accuracy, inconsistent responses, severity and onset not assessed and clinically important interaction not included were common problems. Pharmacist review and validated databases like Lexicomp and Micromedex were more reliable to assess DDI. Conclusion: AI systems can provide support for drug information and may be suitable but are currently not sufficient for autonomous drug information screening. However, pharmacist oversight will remain essential to patient safety, and additional studies are required to develop customizable AI systems for pharmacies that incorporate trusted clinical decision support tools.               Peer Review History: Received 9 April 2026;   Reviewed 11 May 2026; Accepted  13 June; Available online 15 July 2026 Academic Editor: Dr. Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, ahmad.najib@umi.ac.id Reviewers: Dr. Esther Marguerite Chase DJANGA, Faculty of Medicine and Biomedical Sciences. Department of Public Health. University of Yaoundé I, Cameroon. e.djanga@yahoo.com Dr. Dennis Amaechi, MrsFoluBabade Mini Estate , Flat 5 by Old Soldiers Quarter, Sabongari/Bwari, Abuja- Federal Capital Territory, Nigeria. amaechitoexcel@yahoo.com  07 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v11i3.1575 https://ujpronline.com/index.php/journal/article/view/1575 https://ujpronline.com/index.php/journal/article/download/1575/2185 https://ujpronline.com/index.php/journal/article/download/1575/2185 https://ujpronline.com/index.php/journal/article/download/1575/2212 https://ujpronline.com/index.php/journal/article/download/1575/2186