_1789449208 20260915131328000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 09 15 2026 Njoku Juliet Chinomso Anyiam Paul Ndubuisi Alaebo Prince Ogochukwu Chris-Eze Chidinma Esther Ebeleagu Joseph Chidiebere Francis Blessing Chidinma Background and Objective: Monosodium glutamate (MSG)-induced oxidative stress has been implicated in renal dysfunction through excessive generation of reactive oxygen species. Annona muricata is a medicinal plant reputed for its antioxidant and nephroprotective properties. This study evaluated the protective effects of ethanol leaf extract of A. muricata on renal function and serum antioxidant parameters in MSG-intoxicated albino rats. Methods: Thirty male albino rats were randomly assigned into six groups (n = 5). Group I served as the normal control, Group II received MSG (800 mg/kg body weight), Group III received MSG plus silymarin (50 mg/kg), while Groups IV–VI received MSG plus ethanol leaf extract of A. muricata at doses of 200, 400, and 800 mg/kg body weight, respectively, for 14 days. Results: Administration of MSG significantly (p<0.05) increased serum urea, creatinine, sodium, chloride, and MDA concentrations, with concomitant reductions in GSH, GPx, SOD, and CAT activities compared with the normal control. Treatment with A. muricata extract significantly (p<0.05) ameliorated these alterations in a dose dependent manner. The highest dose (800 mg/kg) produced the greatest nephroprotective effect, reducing serum urea (25.03±2.01 mg/dL) and creatinine (0.70±0.03 mg/dL), while significantly increasing GSH (13.70±0.41 µmol/mg protein), GPx (31.37±0.91 µmol/mg protein), SOD (37.76± 0.66 µmol/mg protein), and CAT (16.80±0.81 µmol/mg protein) compared with the MSG-treated group. Conclusion: Ethanol leaf extract of A. muricata demonstrated significant dose-dependent antioxidant and nephroprotective effects against MSG-induced renal toxicity, suggesting its potential as a natural therapeutic agent for the management of oxidative stress-related kidney injury.                   Peer Review History: Received 3 June 2026;   Reviewed 9 July 2026; Accepted  7 August; Available online 15 September 2026 Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, toyinpharm@gmail.com Reviewers: Dr. Rana Ahmed MohamedEl-Saied El-Fitiany, Ahram Canadian University, Giza, Egypt, marmarelfitiany@gmail.com Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my 09 15 2026 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v11i4.1624 https://ujpronline.com/index.php/journal/article/view/1624 https://ujpronline.com/index.php/journal/article/download/1624/2224 https://ujpronline.com/index.php/journal/article/download/1624/2224 https://ujpronline.com/index.php/journal/article/download/1624/2238 https://ujpronline.com/index.php/journal/article/download/1624/2252