_1568871674 1568871674 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 09 15 2018 Khaled Abdulsalam Al-Haddad Omar Ahmed Esma’il Al-dossary Hassan A. Al-Shamahy The objective of this study was to contrast the prevalence and species of colonization of Non-Candida albicans (NCAC) in the oral cavity of denture wearers and non-denture wearers; also asses associated risk factors of their colonization. A total of 208 subjects were studied: 104 denture wearers and 104 non-denture wearers, matched by age, sex, comprised the experimental control groups, respectively. Each subject was instructed to perform oral rinsing using a phosphate-buffered saline solution, which was expectorated processed for the recovery of Candida species on on Sabouraud dextrose agar. Isolates were identified by culturing on chromogenic Candida agar noting species-specific colony characteristics. There was a significant oral carriage rate of NCAC among denture wearers (5.83% versus 11.1% in controls) with associated risk factor (5.4) (PV<0.001). The most common isolated NCAC were C. Krusi  C.tropicalis with significant OR (5.5  4.7 respectively). When co-infections were considered, there was highly significant association of C. albicans + C. krusi oral colonization in cases (OR=4.56, PV<0.001). There was a significant oral carriage rate of NCAC among male denture wearers (36.9%, OR=6.6, PV˂0.001). In addition, there was a significant rate of NCAC colonization with complete denture (rate= 50%, OR=2.4, PV= 0.02). While no significant increase associated with colonization of NCAC with partial, acrylic /or chrome cobalt denture.  Based on the results of this study ability of NCAC were greater in denture wearers than non-denture wearers, also greater risk of NCAC were found with males, older ages, complete denture.                   09 12 2018 10.22270/ujpr.v3i4.176 http://ujpr.org/index.php/journal/article/view/176 http://ujpr.org/index.php/journal/article/download/176/118 http://ujpr.org/index.php/journal/article/download/176/330 http://ujpr.org/index.php/journal/article/download/176/118 http://ujpr.org/index.php/journal/article/download/176/330