_1568872310 1568872310 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 11 15 2018 Oyeniran Taiwo Opeyemi Obanewa opeyemi Adegbenro The present study was carried out to formulate and evaluate multiparticulate system containing mini-tablets of Naproxen sodium. Naproxen is a nonsteroidal anti-inflammatory drug (NSAIDs) with analgesic and antipyretic properties. Pre-formulation studies showed good flow and compaction capacity, leading to the production of high quality mini-tablets. The drug-excipients compatibility studies were performed using FTIR techniques. Ten different matrix mini tablets were manufactured by direct compression using various polymers like HPMC K4M, PVP K30 in different ratio. The prepared mini tablets were subjected to pre and post compressional parameters and the values were within the prescribed limits. The in-vitro performance showed the desired biphasic behaviour. Drug release from matrix mini tablets was sustained over a period of 10 hours and release rate. Study concludes that Naproxen sodium can be successfully released in a controlled manner by the use of developed matrix mini-tablets. Google Scholar 11 15 2018 10.22270/ujpr.v3i5.205 http://ujpr.org/index.php/journal/article/view/205 http://ujpr.org/index.php/journal/article/download/205/141 http://ujpr.org/index.php/journal/article/download/205/359 http://ujpr.org/index.php/journal/article/download/205/141 http://ujpr.org/index.php/journal/article/download/205/359