_1568963529 1568963529 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Felix Sunday Yusuf Yunus A A Dingwoke Francis John Udokwu Japheth Chigbo The present study deals with the formulation and evaluation of Abacavir nanoparticles. Abacavir is an anti-retroviral drug; it is used in treatment of AIDS. Abacavir  nanoparticles were formulated by solvent displacement method using Eudragit RL-100, chitosan and Poloxamer-188. Nanoparticles were characterized by determining its particle size, drug entrapment efficiency, particle morphological character and in-vitro drug release. Particle size range of nanoparticles was in the range of 121.4-140.6 nm. Zeta potential of formulations was determined, and it was found in range of 16.5-20.45 mv. The in-vitro release of nanoparticles were carried out which exhibited a sustained release of Abacavir from nanoparticles up to 10 hrs. The study concludes that nanoparticles can be a promising drug delivery system for sustained release of Abacavir in terms of increased bioavailability. Google Scholar 11 01 2016 10.22270/ujpr.v1i2.R2 http://ujpr.org/index.php/journal/article/view/23 http://ujpr.org/index.php/journal/article/download/23/15 http://ujpr.org/index.php/journal/article/download/23/202 http://ujpr.org/index.php/journal/article/download/23/15 http://ujpr.org/index.php/journal/article/download/23/202