_1568963657 1568963657 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Dingwoke Francis John Unus A A Udokwu Japheth Chigbo Ugwoke Sunday Paul Ezeaku Ikenna Liposomes are colloidal particles formed as concentric bimolecular layers that are capable of encapsulating drugs. Liposomes have the potential for extending the duration of action for days or months. Tolnaftate  is is used as the topical antifungal agent.  The purpose of this study was to provide the delivery of the topical drug at a sustained rate across intact skin to improve bioavailability.  In present study, four different liposomes  formulations of Tolnaftate were prepared by ethanol (solvent) injection method by varying the concentrations of phospholipids. The prepared liposomes were characterized for  size, shape, entrapment efficiency, zeta potential, in-vitro drug release. An in vitro drug release of about 82.114 % in 10 h was observed from optimum formulation of batch LS4. Google Scholar 11 01 2016 10.22270/ujpr.v1i2.R6 http://ujpr.org/index.php/journal/article/view/27 http://ujpr.org/index.php/journal/article/download/27/19 http://ujpr.org/index.php/journal/article/download/27/200 http://ujpr.org/index.php/journal/article/download/27/19 http://ujpr.org/index.php/journal/article/download/27/200