_1568706773 1568706773 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 09 15 2019 Abdullah Hameed Maad Mohammed El-Hassan Ali Shayoub Elamin Ibrahim Elnima Zuheir Osman Fatehalrahman F. Magbool The objective of the present study is to formulate colon targeted matrix tablets containing Solenostemma argel extract using guar gum alone or in combination with either HPMC K15M, with Eudragit S100, or with both them. The Hargel colon targeted matrix tablets were prepared by wet granulation method. The prepared matrix tablets were evaluated for the weight variation, hardness, friability, and in-vitro drug release study in three different media. The formulations showed compliance with pharmacopial standards except that containing guar gum alone. There was no interaction between drug, polymer and other excipients. It was confirmed by FTIR studies. Among the formulations, GHE2 (i.e. containing triple polymer mixture) showed good results in release retardation and other physicochemical properties of matrix tablets when compare to other formulations. The optimum formulation (GHE2) was stable when it was stored at 450/75% RH for 3 months. The formulation GHE2 was considered the most suitable formula for targeted the colon. 09 12 2019 10.22270/ujpr.v4i4.297 http://ujpr.org/index.php/journal/article/view/297 http://ujpr.org/index.php/journal/article/download/297/368 http://ujpr.org/index.php/journal/article/download/297/380 http://ujpr.org/index.php/journal/article/download/297/368 http://ujpr.org/index.php/journal/article/download/297/380