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    <registrant>UJPR</registrant>
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      <journal_metadata>
        <full_title>Universal Journal of Pharmaceutical Research</full_title>
        <abbrev_title>Univ J Pharm Res</abbrev_title>
        <issn media_type="electronic">2456-8058</issn>
      </journal_metadata>
      <journal_issue>
        <publication_date media_type="online">
          <month>09</month>
          <day>15</day>
          <year>2019</year>
        </publication_date>
      </journal_issue>
      <journal_article xmlns:jats="http://www.ncbi.nlm.nih.gov/JATS1" publication_type="full_text" metadata_distribution_opts="any">
        <titles>
          <title>A RECENT OVERVIEW OF LOCALLY ADMINISTERED  TOPICAL OTIC DOSAGE FORMS</title>
        </titles>
        <contributors>
          <person_name contributor_role="author" sequence="first">
            <given_name>Evren ALGIN</given_name>
            <surname>YAPAR</surname>
          </person_name>
          <person_name contributor_role="author" sequence="first">
            <given_name>Umut</given_name>
            <surname>BESKAN</surname>
          </person_name>
          <person_name contributor_role="author" sequence="first">
            <given_name>Sinem Yaprak</given_name>
            <surname>KARAVANA</surname>
          </person_name>
        </contributors>
        <jats:abstract xmlns:jats="http://www.ncbi.nlm.nih.gov/JATS1">
          <jats:p>Ear diseases can significantly affect the life quality of patient, so the need for effective treatment encourages the development of new active substances and new dosage forms. Otic dosage forms may be solutions, suspensions, or emulsions of drops or spray for washing the ear or for administration to the ear canal. They may be ear-wash preparations in the form of solution or emulsion, or medicated semi-solid or solid preparations in the form of gel, cream, ointment, powders, sticks or buffers. These preparations can contain one or much more active ingredients in a suitable vehicle and additionally may contain different excipients for isotonisation, pH adjustment, viscosity or solubility enhancement, buffering, preservation, etc. These excipients should not alter the pharmacological effect of active substances and should not be toxic or irritating. Ear preparations can be packaged in single or multiple doses. It is anticipated that otic dosage forms will be improved and the importance of locally applied, safe and highly controlled drug delivery systems will increase in the future.</jats:p>
        </jats:abstract>
        <publication_date media_type="online">
          <month>09</month>
          <day>12</day>
          <year>2019</year>
        </publication_date>
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