_1573795495 1573795495 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 11 15 2019 BAMBOLA Bouraïma HOUNGBEME Gouton Alba GANDONOU Dossa Clément GBAGUIDI Ahokannou Fernand https://orcid.org/0000-0002-4899-0408 FAGBOHOUN Louis https://orcid.org/0000-0002-7063-8304 GLINMA Bienvenu https://orcid.org/0000-0002-0487-4704 Present work involve study of the toxicity and the antitrypanosomal activity of the hemi syntheses (total of thiosemicarbazones) extracted from the substrates (reagents of thiosemicarbazides) in 1N hydrochloric acid medium from Mitracarpus Scaber harvested in the region of Abomey-calavi. The ethanolic, dichloromethane and hydroethanol extracts (50:50 v/v) yielded the alkaloid extracts with yields of 4.44%, 2.48% and 5.08% respectively leading to three products of hemi-synthesis P1, P2 and P3 whose larval toxicities have respective values LC50: 78.1μg/mL, 95μg/mL, and 48.8 μg/mL whereas the toxicity tests of the alkaloid samples of ethanol, dichloromethane and hydroethanolic E1, E2 and E3 extracted from the evaluation of the same larval toxicity test gave values of 83.41μg/mL 102.51μg/mL and 52.91μg/mL respectively. These results were less toxic than those of semisynthetic products. Acute and sub-acute toxicity in non-pregnant NMRI female mice after oral gavage of P2 product has been shown to be non-toxic. The antitrypanosomal test was carried out according to the Alamar blue method, it revealed that P1 moderately inhibits trypanosome parasites (IC50=18.06 μg/mL) as well as P2 and P3 with a respective IC50 of 17.24 μg/mL and 20, 68 μg/mL while the alkaloid totals had lower antitrypanosomal activity than the hemi-synthesis products. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.5/10 Reviewer(s) detail: Name: Dr. Gehan Fawzy Abdel Raoof Kandeel Affiliation: Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt E-mail: gehankandeel9@yahoo.com   Name: Dr. Dalia Kamal Zaffar Ali  Affiliation: Modern University for technology and information, Egypt E-mail: dr.moda88@gmail.com Comments of reviewer(s): 11 07 2019 10.22270/ujpr.v4i5.314 http://ujpr.org/index.php/journal/article/view/314 http://ujpr.org/index.php/journal/article/download/314/569 http://ujpr.org/index.php/journal/article/download/314/578 http://ujpr.org/index.php/journal/article/download/314/587 http://ujpr.org/index.php/journal/article/download/314/569 http://ujpr.org/index.php/journal/article/download/314/578 http://ujpr.org/index.php/journal/article/download/314/587