_1568957543 1568957543 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Ali Gamal Ahmed Al-kaf Ahmed Mohamed Othman At present scenario many researchers are working to develop technology that promises to deliver the drug in more efficient and less painful way in order to produce the therapeutic effects. Needle-free injection systems are novel ways to introduce various medicines into patients without piercing the skin with a conventional needle. Needle free injection gives very effective injections for a wide range of drugs.  Needle free systems are designed to avoid the problems associated with conventional needles making them safer, less expensive, and more suitable. Additional benefits include very fast injection compared with conventional needles and no needle disposal issues. This review intends to throw light on the basic mechanisms by which this technology works, different types of technologies available at present and its applications. Google Scholar 03 01 2017 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v2i2.RW1 http://ujpr.org/index.php/journal/article/view/40 http://ujpr.org/index.php/journal/article/download/40/29 http://ujpr.org/index.php/journal/article/download/40/221 http://ujpr.org/index.php/journal/article/download/40/29 http://ujpr.org/index.php/journal/article/download/40/221