_1568957439 1568957439 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Uroko Robert Ikechukwu Dingwoke Emeka John Francis Ambi A A Ritonavir is human immunodeficiency virus (HIV) protease inhibitor used as the antiretroviral agent. The objective of the present investigation was to formulate and evaluate Ritonavir gastro-retentive floating microballoons for controlled release. Different batches of microballoons were prepared by the emulsion solvent diffusion method. The resultant microballoons were evaluated for percentage yield, entrapment efficiency, particle size, and in vitro drug release, stability study. The densities of floating microspheres were found to be less than the density of gastric fluid (1.004 g/cm3). The entrapment efficiency of prepared floating microspheres was satisfactory (68.37 to 88.52%). Among all formulations, FM1 prepared with polymer HPMC was found to be the best as it exhibited highest drug release (89.07%) in 12 hrs and was stable for three months at ambient conditions. Google Scholar 03 01 2017 10.22270/ujpr.v2i2.R3 http://ujpr.org/index.php/journal/article/view/47 http://ujpr.org/index.php/journal/article/download/47/34 http://ujpr.org/index.php/journal/article/download/47/218 http://ujpr.org/index.php/journal/article/download/47/34 http://ujpr.org/index.php/journal/article/download/47/218