_1568957507 1568957507 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Fatima A . Adamude Uhama Kingsley Chukwuka Since last decade drugs through skin has received great attention of many researchers. The aim of present study was designed to develop a suitable matrix type transdermal drug delivery system (TDDS) of Losartan potassium using blends of different polymeric combinations of polyvinylpyrrolidone K30 (PVP K30) and ethylcellulose (EC), hydroxypropyl methyl cellulose and chitosan. Physical studies including thickness, folding endurance moisture content, tensile strength and flatness were performed on all formulations. In-vitro diffusion study of 10 hrs was performed by means of Franz diffusion cell. All the formulations were found to be suitable for formulating in terms of physicochemical characteristics. Stability study performed on selective batch, TP1 for 12 weeks at different temperature indicates stability of  transdermal patches at room temperature. Present study concluded that Losartan potassium can be formulated into the transdermal matrix type patches to sustain its release characteristics. Polymeric composition of batch TP1 (PVP K30 : Chitosan:: 70:30) was found to be the best choice for manufacturing transdermal patches of Losartan potassium among the formulations studied. 03 01 2017 10.22270/ujpr.v2i2.R5 http://ujpr.org/index.php/journal/article/view/49 http://ujpr.org/index.php/journal/article/download/49/36 http://ujpr.org/index.php/journal/article/download/49/220 http://ujpr.org/index.php/journal/article/download/49/36 http://ujpr.org/index.php/journal/article/download/49/220