_1610687227 1610687227 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 01 15 2021 Zainal Abidin https://orcid.org/0000-0003-0371-444X Asriani Suhaenah https://orcid.org/0000-0003-2168-589X Maya Sari https://orcid.org/0000-0003-2049-7248 Cassava Leaves (Manihot esculenta Crantz) is one of the food resources that many people consume as vegetables in some regions. People believe that it has natural antioxidant compounds such as phenolic and flavonoids.  Also,  it  contains  HCN  elements  known  as  toxic  compounds. However, HCN levels can be reduced by dry heating and boiling. Phenolic and flavonoids are not resistant to heating and are easily oxidized. This article aim to assess the effect of temperature to antioxidant activity and the decrease of HCN level of cassava leaves. The pretreatment  heating  by oven (dry heating) and cooking (boiling heating) greatly affects to the antioxidant activity and  the reduction of cyanide acid (HCN) level in cassava leaves. This article may be useful for any one or any researcher to determine pretreatment heating temperature and heating method  to process prepare cassava leaves.                        Peer Review History: Received 6 November  2020; Revised 25 Decembe; Accepted 4 January, Available online 15 January 2021 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:                           Comments of reviewer(s):         Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com Similar Articles: PHYTOCHEMICAL INVESTIGATION AND EVALUATION OF ANTIOXIDANT AND THROMBOLYTIC PROPERTIES OF LEAVE EXTRACTS OF GARDENIA CORONARIA BUCH-HAM PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT AND ANTI-DIABETIC POTENTIALS OF PERSEA AMERICANA MILL. (LAURACEAE) FRUIT EXTRACT 01 15 2021 10.22270/ujpr.v5i6.515 http://ujpr.org/index.php/journal/article/view/515 http://ujpr.org/index.php/journal/article/download/515/866 http://ujpr.org/index.php/journal/article/download/515/876 http://ujpr.org/index.php/journal/article/download/515/889 http://ujpr.org/index.php/journal/article/download/515/866 http://ujpr.org/index.php/journal/article/download/515/876 http://ujpr.org/index.php/journal/article/download/515/889