_1568958097 1568958097 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Okorochukwu Nnamdi Ihuaku Emmanuel C. Pregabalin is a structural analogue of the inhibitory neurotransmitter γ-amino butyric acid (GABA) having short half-life (5-6 hrs) and is used in the management of epilepsy. The aim of this study was to prepare a buccal patch containing Pregabalin by the means of solvent casting method. Six formulations were prepared using different ratio of polymers including HPMC K4M, Eudragit RL, and PVP K30. Since buccal mucosa is relatively permeable with rich blood supply and acts as an excellent site for the absorption of drugs so, it is an attractive alternate to other conventional methods of systemic drug administration. Franz diffusion cell with commercially available dialysis membrane was used for the in-vitro diffusion study of buccal patches for duration of 12 hrs. Kinetics and mechanism of drug release from all formulation was evaluated on the basis of zero order, first order, Hixon-Crowell, Higuchi equation and Peppas model. Based on different parameters i.e. folding endurance, drug content, moisture absorption, moisture loss, water vapor transmission rate in-vitro release study buccal patches of batch F4 (HPMC K4M and Eudragit RL 100) was found to an optimum formulation. 05 01 2017 10.22270/ujpr.v2i3.R2 http://ujpr.org/index.php/journal/article/view/52 http://ujpr.org/index.php/journal/article/download/52/38 http://ujpr.org/index.php/journal/article/download/52/225 http://ujpr.org/index.php/journal/article/download/52/38 http://ujpr.org/index.php/journal/article/download/52/225