_1568958124 1568958124 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Anyanwu NC J Adogo L Y Ajide B The aim of this study was to develop a novel gastro retentive oral floating in situ gelling system for controlled release of Meloxicam. Meloxicam is a NSAID that inhibits cyclooxygenase (COX) synthesis and has analgesic and antipyretic effects. Four polymer based floating in situ gelling systems of Meloxicam were prepared by dissolving varying concentrations of different ingredients including sodium alginate, HPMC K100M, calcium carbonate, sodium citrate. The prepared gels were characterized for solution viscosity, pH, gelling capacity, floating lag time, floating duration and in-vitro release study. All the formulations showed instant gelation maintaining integrity for at least 12 h. The study demonstrated that a stomach specific in-situ gel of Meloxicam could be prepared using the floating mechanism to increase the residence time of the drug in the stomach and improve bioavailability and thus improve patient compliance. Google Scholar 05 01 2017 10.22270/ujpr.v2i3.R3 http://ujpr.org/index.php/journal/article/view/53 http://ujpr.org/index.php/journal/article/download/53/39 http://ujpr.org/index.php/journal/article/download/53/226 http://ujpr.org/index.php/journal/article/download/53/39 http://ujpr.org/index.php/journal/article/download/53/226