_1568958446 1568958446 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Vani R Sunitha M A new simple, accurate, precise and reproducible RP-HPLC method has been developed for the simultaneous estimation of Aspirin and Omeprazole in bulk and pharmaceutical dosage form using C18 column (Agilent, 250 x 4.6 mm, 5 μm) in isocratic mode. The mobile phase consisted of Methanol and 0.1 M Dipotassium Phosphate buffer (pH 3) in the ratio of 60:40 v/v. The detection was carried out at 256 nm. The method was linear over the concentration range for Omeprazole 50-250 μg/ml and for Aspirin 10-50 μg/ml. The recoveries of Omeprazole and Aspirin were found to be 100.07 and 100.06% respectively. The validation of method was carried out utilizing ICH-guidelines. The described HPLC method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form. Google Scholar 07 01 2017 10.22270/ujpr.v2i4.R6 http://ujpr.org/index.php/journal/article/view/68 http://ujpr.org/index.php/journal/article/download/68/52 http://ujpr.org/index.php/journal/article/download/68/237 http://ujpr.org/index.php/journal/article/download/68/52 http://ujpr.org/index.php/journal/article/download/68/237