_1568870079 1568870079 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 06 2018 Nesreen F. Al-Sanabani Abbas M Al-Kebsi Hassan A. Al-Shamahy Al-Kasem M A Abbas Denture stomatitis (DS) is a benign condition, usually asymptomatic, that can affect denture wearers patients. The aims of this study was to describe the etiology of DS among Yemeni denture wearers and the risk factors of DS. A cross sectional study was carried out at Prothodontics Departments at the Faculty of Dentistry- Sana'a University, Sana’a city – Yemen. The study group consisted of 288 denture wearers' patients' contracting DS. The microbiological samples were collected by wiping sterile swabs on upper and lower denture fitting surfaces. Then, they were directly cultured for Candida in Chromomeric agar media and for bacteria in standard selective media, using standard bacteriological methods. The most common microbial cause of DS was C. albicans (58.3%), followed by S. mutans (17%), while S. aureus (4.9%), lactobacillus (3.1%) and C. glabrata (4.2%) were less common. There was an association between male patients, older age group and longer period of denture wearers with high risk of contracting candidal DS and bacterial DS. Most of those patients were suffering from DS Type I and few from Type II, but no case of DS Type III was found. Ending, DS is a condition that commonly affects denture wearers, and should be treated even if asymptomatic. The condition requires a combined treatment approach from both patient and clinician, and the role of the patient must be stressed. Management of aetiological risk factors is key in order to prevent recurrence. Treatment modalities may include: treatment of any underlying systemic risk factors, improvement in the fit of existing dentures, replacement of existing dentures, improved denture hygiene and the use of antifungal agents. Whichever methods are employed, the main aim of treatment is to eradicate the biofilm from the patient’s dentures. Google Scholar 04 01 2018 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v3i1.R9 http://ujpr.org/index.php/journal/article/view/81 http://ujpr.org/index.php/journal/article/download/81/61 http://ujpr.org/index.php/journal/article/download/81/277 http://ujpr.org/index.php/journal/article/download/81/61 http://ujpr.org/index.php/journal/article/download/81/277