_1568962121 1568962121 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Nweje-Anyalowu Paul C Anyalogbu Ernest A A White Alalibo Jim At present scenario the drug regimen based on circadian rhythm is recently gaining much attention worldwide by researchers. Justification behind it is that, there are various diseases like asthma, hypertension, and arthritis show circadian variation that demand time scheduled drug release for effective drug action. A chronodelivery system, based on biological rhythms, is a state-of the- art technology for drug delivery. The aim of present work is formulate and evaluate a press coated pulsatile release tablets of Cilnidipine using an admixture of hydrophilic polymer i.e. hydroxypropyl methyl cellulose (HPMC) and pH sensitive polymers (ethyl cellulose, eudragit S-100) in order to achieve a predetermined lag time for chronopharmacotherapy of Hypertension. Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function used for the treatment of hypertension. The tablets prepared were evaluated for different properties like bulk density, tapped density, Angle of repose and Carr’s index), hardness, thickness, weight variation, friability, drug content uniformity and in vitro drug release study. Google Scholar 09 01 2017 10.22270/ujpr.v2i5.R4 http://ujpr.org/index.php/journal/article/view/84 http://ujpr.org/index.php/journal/article/download/84/65 http://ujpr.org/index.php/journal/article/download/84/247 http://ujpr.org/index.php/journal/article/download/84/65 http://ujpr.org/index.php/journal/article/download/84/247