_1568962148 1568962148 Editor editor.jddt@gmail.com UJPR Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 04 11 2018 Edenta Chidi Nwobodo Ndubuisi Nwobodo Offiah Raymond O In the current pharmaceutical research fast dissolving films are playing an important role. In the present research, five different rapidly dissolving films of Aripiprazole were prepared successfully by using different polymer such as hydroxypropyl methyl cellulose (HPMC-E5 LV), polyvinyl pyrollidone by means of solvent casting method. Citric acid as saliva stimulating agent, mannitol as sweetening agent and menthol was used as flavoring agent. Aripiprazole, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. The prepared films were evaluated for different parameters including thickness, mass uniformity, pH, folding endurance, drug content uniformity, cumulative percent release, in-vitro dissolution test and accelerated stability studies. In-vitro dissolution studies were performed dissolution guidelines for about 30 minutes. For analyzing the mechanism of drug release kinetics of the films, the data obtained were fitted to various kinetic equations of zero order, first order, Higuchi model and Korsmeyer-Peppas model. On the basis of different evaluated parameters formulation of batch F4 was found to be optimum formulation. The optimized formulation F4 was evaluated for the stability studies at 400 C, 75% RH for 45 days. From the evaluation, it was found that there is no significant change in appearance, pH, folding endurance, drug content, in vitro disintegration and percentage drug release. 09 01 2017 10.22270/ujpr.v2i5.R5 http://ujpr.org/index.php/journal/article/view/85 http://ujpr.org/index.php/journal/article/download/85/66 http://ujpr.org/index.php/journal/article/download/85/248 http://ujpr.org/index.php/journal/article/download/85/66 http://ujpr.org/index.php/journal/article/download/85/248