_1673785956 20230115123236000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 01 15 2023 Ibrahim Zaid Al-Shami https://orcid.org/0000-0001-8421-2278 Yaser Ahmed Salem Alrubaidi https://orcid.org/0000-0002-2551-7255 Khaled A AL-Haddad https://orcid.org/0000-0001-5329-7854 Mohammed Mohammed Ali Al-Najhi https://orcid.org/0000-0002-0642-2154 Hassan Abdulwahab Al-Shamahy https://orcid.org/0000-0001-6958-7012 Taghreed Ahmed M Al-Kibsi https://orcid.org/0000-0003-4921-6868 Abdulwahab Ismail Mohamed Al-Kholani https://orcid.org/0000-0002-2168-0469 Background and aims: Wearing a removable dental prosthesis causes a change in the micro flora of the mouth. The aim of this research was to verify the composition of aerobic bacterial in the oral cavity of patients with removable dentures and with normal teeth (without dentures), and antibiotics pattern for common isolates. Methods: Bacteriological investigations were performed in 122 individuals (61 removable dentures: 61 normal teeth) attending dental clinics of Faculty of dentistry, Sana’a University, Yemen and private dental clinics. The culturing and antibiotic sensitivity were conducted in the Microbiology Department of the National Center of Public Health Laboratories (NCPHL) Sana'a, Yemen. Tongue dorsa and palate mucosa swabs were collected from normal teeth and denture groups, and as well swabs from mucosal part of denture surfaces in prosthetic patients. Cultivation in microaerophilic (5% CO2) and oxygenic conditions were performed on solid selective and non-selective media in addition to media enriched with 5% blood. Results: Regarding the prosthetic patients, the rate of bacterial isolates from the palate, back, tongue and dental plaque smears was higher potential pathogenic bacteria as S. aureus and Enterobacteriaceae spp  in denture wearers, as E. coli (6.6% in dentures vs. 1.6% in the absence of dentures), Klebsiella pneumoniae (11.4% in dentures versus 1.6% in the normal teeth) and Pseudomonas aeruginosa (13.1% versus 0.0% ).While in viridians Streptococcus including Strept .mutans, there was a lower colonization rate in denture patients (18% in palate verses, 73.8% in individuals without dentures). Conclusion: The study demonstrated an elevated rate of bacterial isolates from palate, back, tongue and plaque swabs in denture patients of pathogenic bacteria such as S. aureus, E. coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa; while in Streptococcus viridians including S. mutans, there was a lower colonization rate in denture patients verses a very high rate in individuals without dentures.                       Peer Review History: Received: 7 November 2022; Revised: 13 December; Accepted: 8 January 2023, Available online: 15 January 2023 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, ahmad.najib@umi.ac.id Received file:                             Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Alfonso Alexander Aguileral, University of Veracruz,  Mexico, aalexander_2000@yahoo.com Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com Similar Articles: ETIOLOGY AND RISK FACTORS OF STOMATITIS AMONG YEMENI DENTURE WEARERS PREVALENCE AND ASSOCIATED FACTORS OF ORAL NON-CANDIDA ALBICANS CANDIDA CARRIAGE IN DENTURE WEARERS IN SANA'A CITY- YEMEN THE EFFECT OF NANOSILVER AND CHLORHEXIDINE MOUTHWASH ON ANAEROBIC PERIODONTAL PATHOGENS COUNTS 01 15 2023 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v7i6.862 https://ujpr.org/index.php/journal/article/view/862 https://ujpr.org/index.php/journal/article/download/862/1311 https://ujpr.org/index.php/journal/article/download/862/1311 https://ujpr.org/index.php/journal/article/download/862/1320 https://ujpr.org/index.php/journal/article/download/862/1329