_1678857282 20230315051442000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 03 15 2023 Abdul Salam Mohamed Al Makdad https://orcid.org/0000-0001-6485-5655 Abdulrahman Y. Al-Haifi https://orcid.org/0000-0001-7242-7052 Najlaa Abdullah Mohammed Al-Mutaa https://orcid.org/0009-0001-8065-4770 Hassan Abdulwahab Al-Shamahy https://orcid.org/0000-0001-6958-7012 Background: Hepatitis B virus (HBV) is a most important health problem, it's a global pandemic. Previous surveys showed a high prevalence of hepatitis B infection in Yemen. Hepatitis B vaccination is the most efficient way to prevent hepatitis B virus infection and its outcomes (such as hepatocellular carcinoma, cirrhosis, and liver failure). Aim: To measure the immune status of hepatitis B virus amongst first-year students at the faculties of Thamar University during the academic year 2021-2022. Methods: A total 196 of first-year students participated in this cross-sectional study and tested for anti-HBsAg and the antibody to HBV core antigen (anti-HBc) and HBsAg by using ELISA during the period from January to May 2022 at Thamar University. An anti-HBs antibody titer ≥10 mIU/mL was regarded as being protective against HBV infection. Results: In this study, 22.4% of the students had protective levels against hepatitis B, while 77.6% had a non-protective level. HBV markers showed that 19.90%, 2.55%, and 75.51% of the students had been vaccinated and immunized due to a previous infection and exposed to HBV infection respectively and only 2.04% of them were non-obvious cases. The prevalence of anti-HBc was 4.6%. Risk factors that showed statistical significance were found between positive anti-HBc and family history of HBV (p=0.01). Conclusion: The low prevalence of hepatitis B protection levels in Thamar University medical students needs further research and necessitates implementation of a screening and vaccination program for all non-immunized healthcare students.                         Peer Review History: Received: 24 December 2022; Revised: 13 February 2023; Accepted: 8 March 2023, Available online: 15 March 2023 Academic Editor: Dr. Iman Muhammad Higazy, National Research Center, Egypt, imane.higazy@hotmail.com Received file:                             Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Rola Jadallah, Arab American University, Palestine, rola@aauj.edu Dr. Wadhah Hassan Ali Edrees, Hajja University, Yemen, edress2020@gmail.com Similar Articles: PREVALENCE OF HEPATITIS A VIRUS, HEPATITIS B VIRUS, AND HEPATITIS C VIRUS, AMONG PATIENTS WITH HEPATIC JAUNDICE IN SANA’A CITY, YEMEN: A HOSPITAL BASED STUDY PREVALENCE OF DIFFERENT HEPATITIS B VIRUS GENOTYPES AND RISK FACTORS ASSOCIATED AMONG SELECTED YEMENI PATIENTS WITH CHRONIC HEPATITIS B INFECTION 03 15 2023 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v8i1.900 https://ujpr.org/index.php/journal/article/view/900 https://ujpr.org/index.php/journal/article/download/900/1350 https://ujpr.org/index.php/journal/article/download/900/1350 https://ujpr.org/index.php/journal/article/download/900/1360 https://ujpr.org/index.php/journal/article/download/900/1372