_1689398090 20230715051450000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 07 15 2023 Wedad Omar Ali Elaiwa https://orcid.org/0009-0006-1399-1810 Ibrahim Zaid Al-Shami https://orcid.org/0000-0001-8421-2278 Mohsen AL-Hamzi https://orcid.org/0000-0003-3851-9177 Abdul Wahab Al-kholani https://orcid.org/0000-0002-2168-0469 Mokhtar Abd Hafiz Abd Alhamid Al-Ghorafi https://orcid.org/0009-0007-0357-1780 Nagwa Othman https://orcid.org/0000-0001-7208-6024 Objective: The aim of this study was to determine the efficacy of a homemade tooth-whitening recipe using Dracaena cinnabari (DC) resin, which is traditionally used for tooth decay treatment and cleaning in Soqatra. The study investigated the antioxidant activity of the resin extracts in methanol as tooth-whitening natural product. Materials and Methods: A total of 40 bovine teeth with initial color B2 were selected and divided into four groups. One group was kept as a negative control, while the other three were stained with Yemeni coffee solution for one week. The first group was treated with 10% carbamide peroxide (CP) home bleaching, the second group was treated with 10% DC gel with rubbing movement (DC Ru), and the third group was treated with 10% DC gel without rubbing (DC) for 6 hours daily for 14 days. Color measurements were taken at different time points using a spectrophotometer device. Results: All experimental gels resulted in greater color change compared to the negative control, with DC Ru showing the greatest ΔE* value (p<.001) compared to the DC group (p<.006) and the CP group (p<.001). The second reading of stabilization of all gels resulted with resembled ΔE* values to the first reading of stabilization.  Conclusion: The study suggests that the experimental gels containing phenolic content with strong antioxidant effects may reserve significant clinical potential as active agents for tooth-whitening without using HP/CP. Further studies are needed to measure the effect on surface roughness and color stability.                            Peer Review History: Received: 9 March 2023; Revised: 23 April; Accepted: 25 June 2023, Available online: 15 July 2023 Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com Received file:                             Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Prof. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com 07 15 2023 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v8i3.945 https://ujpr.org/index.php/journal/article/view/945 https://ujpr.org/index.php/journal/article/download/945/1414 https://ujpr.org/index.php/journal/article/download/945/1414 https://ujpr.org/index.php/journal/article/download/945/1422 https://ujpr.org/index.php/journal/article/download/945/1434