_1689397984 20230715051304000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 07 15 2023 Riyadh Saif-Ali https://orcid.org/0000-0002-0246-3856 Background and objectives: Serine racemase (SRR) and protein tyrosine phosphatase receptor type D (PTPRD) were suggested as Type 2 diabetes mellitus (T2DM) candidate genes by a genome-wide association study (GWAS) in the Chinese population. Association of SRR and PTPRD with T2DM have been reported among East Asian Populations. The association of SRR and PTPRD genetic polymorphisms with T2DM still needs to be studied in Southeast Asian Populations. Materials and Methods: This study aimed to evaluate the association of SRR and PTPRD genetic polymorphisms with T2DM in Malay subjects. The single nucleotide polymorphisms (SNPs) of SRR (rs4523957, rs391300, and rs8081273) and PTPRD (rs17584499 and rs649891) were genotyped in 440 T2DM and 398 normal Malay subjects.  Results: The recessive genetic model showed that SRR genotype GG of rs4523957 and genotype TT of rs391300 are risk factors for T2DM (OR=1.42; 1.45, p=0.022; 0.020, respectively), whereas the dominant and additive genetic models showed that PTPRD SNPs rs17584499 were protective for T2DM (OR=0.76; 0.77, p=0.033; 0.031, respectively).  Conclusion: This study replicated the association of SRR rs4523957, rs391300, and PTPRD rs17584499 genetic polymorphisms with T2DM in Malay, while more investigation in different populations is required to confirm this finding.                          Peer Review History: Received: 9 March 2023; Revised: 23 April; Accepted: 26 June 2023, Available online: 15 July 2023 Academic Editor: Dr. Amany Mohamed Alboghdadly, Ibn Sina National College for Medical Studies in Jeddah, Saudi Arabia, amanyalboghdadly@gmail.com  Received file:                             Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Rola Jadallah, Arab American University, Palestine, rola@aauj.edu Dr. Dennis Amaechi, MrsFoluBabade Mini Estate , Flat 5 by Old Soldiers Quarter, Sabongari/Bwari, Abuja- Federal Capital Territory, Nigeria. amaechitoexcel@yahoo.com 07 15 2023 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v8i3.946 https://ujpr.org/index.php/journal/article/view/946 https://ujpr.org/index.php/journal/article/download/946/1415 https://ujpr.org/index.php/journal/article/download/946/1415 https://ujpr.org/index.php/journal/article/download/946/1423 https://ujpr.org/index.php/journal/article/download/946/1432