_1689398166 20230715051606000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 07 15 2023 Ezegbe Chekwube Andrew https://orcid.org/0000-0003-2831-1006 Ezegbe Amarachi Grace https://orcid.org/0000-0002-5026-0690 Chime Amarachi Salome https://orcid.org/0000-0001-8082-121X Ugwu Calister Elochukwu https://orcid.org/0000-0002-6656-7902 Boniface Christian Izuchukwu https://orcid.org/0000-0002-4858-9155 Ugwuoke Kenneth Ejiofor https://orcid.org/0000-0003-3317-3023 Chukwuemeka Chizoba Lorrita https://orcid.org/0000-0003-2402-5088 Onunkwo Godswill https://orcid.org/0000-0003-3559-7858 Introduction:  Metronidazole is a synthetic oral nitroimidazole antibiotic used in the treatment of infections caused by anaerobic bacteria and protozoa. It also has amebicidal and antiprotozoal properties. Aim: The purpose of the study was to formulate and evaluate metronidazole tablets formulated with polymers (PVP and PEG) and maize starch as disintegrant using moisture activated dry granulation (MADG). Method: Twenty-four (24) batches of metronidazole granules and tablets were prepared by moisture activated dry granulation.  Metronidazole (200 mg), lactose and gelatin (1, 2, 4, and 8 %) were mixed, followed by continuous mixing. Prior to compression, micro-crystalline cellulose, disintegrants and magnesium stearate were added. The dried granules were passed via 1.0 mm sieve after which they were labelled and stored in an air tight container. All other batches were also similarly prepared. Result: The result showed that the mean weight of the tablets ranged from 0.33±0.01 to 0.35±0.04 g. Tablet hardness ranged from 5.00±0.85 to 6.36±1.43. The results showed that batch 11 tablets had higher crushing strength than batch 24 with a significant difference. Table 2 shows the hardness test results and clearly indicates that the results of all the samples significantly differ from each other (p<0.05). The tablet friability test ranged from 0.21±0.17 for batch 24 and 0.60±0.16 for batch 11.  The formulated tablets showed average disintegration time ranges from 0.52±0.01 to 14.03±0.03. According to USP, the disintegration time must be in the range of 15 min for uncoated tablets, and 30 mins for film coated tablets. Conclusion: The study established that polyethylene glycol and polyvinyl pyrrolidone polymers had better dissolution profile than maize starch which has the best disintegration properties.                          Peer Review History: Received: 4 March 2023; Revised: 26 April; Accepted: 20 June 2023, Available online: 15 July 2023 Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com Received file:                             Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Julie Ann S. Ng, Blk 18 Lot 6 Grandville 3 Subdivision Mansilingan, Bacolod City, Philippines.  julieann_ng@yahoo.com Dr. Essam Mohamed Eissa, Beni-Suef – 32 Tahrir St, Egypt, dressamceutics@yahoo.com 07 15 2023 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v8i3.951 https://ujpr.org/index.php/journal/article/view/951 https://ujpr.org/index.php/journal/article/download/951/1418 https://ujpr.org/index.php/journal/article/download/951/1418 https://ujpr.org/index.php/journal/article/download/951/1425 https://ujpr.org/index.php/journal/article/download/951/1437