_1694760965 20230915065605000 Editor editor.jddt@gmail.com Universal Journal of Pharmaceutical Research Universal Journal of Pharmaceutical Research Univ J Pharm Res 2456-8058 2831-5235 09 15 2023 Herrera-Ruiz Maribel https://orcid.org/0000-0001-9056-3568 Jiménez-Ferrer Enrique https://orcid.org/0000-0002-0783-8274 Zamilpa Alejandro https://orcid.org/0000-0002-2233-5958 Jiménez-Aparicio Antonio Ruperto https://orcid.org/0000-0002-7748-4432 Arenas-Ocampo Martha Lucía https://orcid.org/0000-0002-4400-5482 Monterrosas-Brisson Nayeli https://orcid.org/0000-0002-4449-5813 Background: The systemic administration of Lipopolysaccharide (LPS) is a pharmacological model to evaluate different processes associated with neurodegeneration; it is capable of causing an increase in the oxidative state in the brain and increasing the activity of the enzyme acetylcholinesterase (ACh-E), involved in the degradation of acetylcholine (ACh). This cholinergic transmission system participates in memory processes, a crucial symptom in neurodegenerative disorders, and its modulation with scopolamine turns out to be an essential tool in the evaluation of plants. Species of the genus Agave are considered a natural resource of economic and cultural importance in Mexico. They possess compounds with anti-inflammatory, antioxidant, and anti-neuroinflammatory activities. Methods: Extracts of A. tequilana (At-A), A. angustifolia (Aan-A), A. americana (Aam-A) at 125 mg/kg were administered to male ICR mice with LPS to evaluate the ACh-E inhibition, the concentration of the antioxidant enzyme Gluthatione Reductase (GR) and the prooxidant enzyme NADPH Oxidase (NOX). Also, the nootropic effect of these extracts on scopolamine-induced cognitive impairment was evaluated. Results: The three Agave species studied decreased the ACh-E enzyme activity, Vmax value, and KM. These products increased the GR concentration from 0.173±0.003 (vehicle) to 0.642±0.002 µMol/mg in At-A, which was the highest one. Regarding NOX, only the A. tequilana extract decreased it (0.513±0.002µMol/mg)compared with Vehicle (0.621±0.008µMol/mg). A. tequilana and A. americana species significantly improved the retention latency parameter (260 seconds) during the passive avoidance test. Conclusion: Agave species showed promising results in developing novel drugs for neurodegenerative disease therapy.                         Peer Review History: Received: 17 June 2023; Revised: 22 July; Accepted: 27 August, Available online: 15 September 2023 Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com Received file:                             Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Prof. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com 09 15 2023 http://creativecommons.org/licenses/by-nc/4.0 10.22270/ujpr.v8i4.970 https://www.ujpr.org/index.php/journal/article/view/970 https://www.ujpr.org/index.php/journal/article/download/970/1442 https://www.ujpr.org/index.php/journal/article/download/970/1442 https://www.ujpr.org/index.php/journal/article/download/970/1452 https://www.ujpr.org/index.php/journal/article/download/970/1462