THE ASSOCIATION OF ADULT MALE AND FEMALE INFERTILITY WITH CELIAC DISEASE PATIENTS IN YEMEN

Al-Anesi Mohsen; Qiping Hu; Ekram Al-Eryani; Mansour Al-Amrani; Hassan Al-Shamahy

doi:10.22270/ujpr.v2i6.R5

Al-Anesi Mohsen Department of biochemistry and molecular biology, Guangxi Medical University, China
Qiping Hu Department of biochemistry and molecular biology, Guangxi Medical University, China
Ekram Al-Eryani Department of biochemistry, Faculty of Medicine and Heath Sciences, Sana’a University, Yemen
Mansour Al-Amrani Department of biochemistry, Faculty of Medicine and Heath Sciences, Sana’a University, Yemen
Hassan Al-Shamahy Faculty of Medicine and Heath Sciences, Sana’a University, Yemen

10.22270/ujpr.v2i6.R5

Keywords:

Celiac disease, infertility, sex hormones, Sana’a, Yemen

Abstract

Objectives: Celiac disease’s potentially destructive effect on reproductive health is among the most vital matters associated with progress awareness. Men and women with unexplained infertility, women with recurrent abortions, intrauterine growth retardation, low birth weight babies and menstrual disorders are not often screened for celiac disease (CD) despite scientific studies that point to a correlation. The aims of the present study were to examine the evidence of the correlation between CD and infertility by measuring sex hormones in CD comparing healthy controls (HC).

Methods: The study was carried out in Autoimmune Unit, AL-Thowra Hospital Sana’a city, Yemen. The study included 32 CD patients, and 32 HC. Blood samples were collected then examined for sex hormones in both.

Results: There was highly significant low down level of the mean±SD of sex hormones among male and female CD than HC: for male CD FSH=1.96±1.4 IU/ml vs 3.3±1.27 IU/ml of HC, LH=3.9±3.3 IU/ml vs 6.5±2.03 IU/ml of HC; and the testosterone=1.03±0.76 IU/ml, vs 3.8±1.4 IU/ml of HC. For CD females the mean ± SD of FSH, for CD females was 4.37±2.46 IU/ml vs 4.92±2.35 IU/ml of HC, Estradiol (40.7±30.8 IU/ml vs 7.1±76.66 IU/ml of HC), and Progestrone (1.2±1.15 IU/ml, vs 6.4±4.38 IU/ml of HC).

Conclusion: In conclusion, there was significant association between CD and infertility among Yemeni CD patients in which it indicated by low sex hormones in CD patients.

Peer Review History:

Received 3 October 2017; Revised 12 November; Accepted 25 December, Available online 15 January 2018

Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com