ANTIBIOTICS CONSUMPTION AMONG HOSPITALIZED PATIENTS IN INTENSIVE CARE UNITS AT SANA’A CITY, YEMEN

Abstract

Background: Monitoring antibiotic consumption is crucial to addressing antimicrobial resistance. The aim of current study was to investigate the use and consumption of antibiotics in an intensive care unit in Sana'a, Yemen using DDD and DOT methods, and to our knowledge it is the first of its kind to study this topic.

Methods: A retrospective study on data from the ICU register. The study was carried out from September 2021 to February 2022 on hospitalized  patients of five ICUs of main hospitals at 2020. Antimicrobial consumption data were mostly collected manually. Data were analyzed and presented as defined daily dose (DDD) and days of therapy (DOT) per 1000 patient-days.

Results: A total of 1970 patients were included in this study and the overall consumption of antibiotics in ICUs was as high as 18,017.91 DDD per 1000 patient-days and as high as 17448.73 DOT per 1000 patient-days. The study results found that ceftriaxone, vancomycin, and meropenem were most frequently consumed using DDD and DOT methods among ICU patients, with results by DDDs per 1000 patient-days being 2479.23, 2124.55, and 1830.54, respectively, and results by DOTs per 1,000 patient days being 2,112.69. 2055.33 and 1890.86. The highest amount of antibiotics consumption among WHO AWaRe classification was for "watch" group of 26267.4 and 14674.5 DDDs per 1000 patient per day.

Conclusions: A high consumption of antimicrobial agents such as ceftriaxone, vancomycin and meropenem was found in ICUs of five selected hospitals. There was a significant increasing in “Watch” group antibiotics use and about three-fourths of the prescribed antibiotics were from this group. The study results can be used as a basis before designing any intervention aimed at improving antibiotic use in hospital intensive care units.

                   

Peer Review History:

Received 21 March 2024;   Revised 4 May 2024; Accepted 26 June; Available online 15 July 2024

Academic Editor: Dr. Rola Jadallah, Arab American University, Palestine, rola@aauj.edu

Average Peer review marks at initial stage: 5.5/10

Average Peer review marks at publication stage: 7.0/10

Reviewers:

Dr. Mahmut Yıldıztekin, Muğla Sıtkı Koçman University, Turkey, mahmutyildiztekin@mu.edu.tr

Dr. Masoumeh Divar, Shiraz University, Shiraz, Iran, zhaledivar@gmail.com