ACORUS CALAMUS L ON TYPE 2 DIABETES MELLITUS MEDICATION

Abstract

Diabetes is one of the metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Type 2 diabetes, which accounts for ~90–95% of those with diabetes, the cause is a combination of resistance to insulin action and an inadequate compensatory insulin secretory response. Adequate glycemic control is thus one of the key factors to treat and/or reduce the diabetes and many plants have been used to reduce the glucose level by inhibiting the α-glucosidase that breaks down starch and disaccharides to glucose. Acorus calamus L (AC), a folk medicine to treat type 2 diabetes. In vitro α-glucosidase assay were carried out by measuring the release of p-nitrophenol, the insulin sensitizing activity, AC significantly decreased fasting serum glucose, and suppressed the increase of blood glucose levels after 2g/kg glucose loading in normal mice, in silico study showed that chemical compound on AC can inhibit α-glucosidase and the present study is designed to investigate the effects and molecular mechanisms of AC on glucagon-like peptide-1 (GLP-1) expression and secretion related to its hypoglycemic effects.

                      

Peer Review History:

Received 5 February 2020; Revised 11 March; Accepted 26 April; Available online 15 May 2020

Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, toyinpharm@gmail.com

Received file:                Reviewer's Comments:

Average Peer review marks at initial stage: 5.5/10

Average Peer review marks at publication stage: 7.5/10

Reviewer(s) detail:

Dr. Mohamed Said Fathy Al-Refaey, University of Sadat City, Menofia, Egypt, mido_ph212@yahoo.com

Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, gehankandeel9@yahoo.com