SOLID DISPERSION TECHNOLOGY, A CONTEMPORARY OVERVIEW ON A WELL ESTABLISHED TECHNIQUE

Mahmoud A. Younis

doi:10.22270/ujpr.v2i3.RW1

Mahmoud A. Younis Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

10.22270/ujpr.v2i3.RW1

Keywords:

Dissolution rate, hydrophilic carriers, poorly-soluble drugs, solid dispersion, solubility

Abstract

Solubility is a significant physicochemical parameter that affects the absorption, bioavailability and therapeutic effectiveness of any drug. Formulation development would fail if drug has a poor aqueous solubility. The low aqueous solubility of drug substances will lead to inadequate absorption and consequently, low bioavailability. Improvement of the aqueous solubility and dissolution rate of hydrophobic drugs remains one of the most difficult challenges in drug development process. Among various techniques used to improve poor aqueous solubility of drugs, solid dispersion technology has been extensively used in the literature and has become one of the well-established pharmaceutical procedures during formulation process. Although the technique seems to be “a part of the past”, literature tells us that it is still used and developed to suit current needs of pharmaceutical industry. This review article highlights recent advances in solid dispersion technology and its applications in contemporary pharmaceutical research.