ASSOCIATION OF EPSTEIN-BARR VIRUS WITH SYSTEMIC LUPUS ERYTHEMATOSUS BY LIMITED MATERIALS: PATIENT CHARACTERISTICS AND CLINICAL MANIFESTATIONS IN YEMEN

Mohammed Ismail Al-Mansor; Khaled Abdul-Karim A Al-Moyed; Mohammed Mohammed Al-Shehari; Hassan Abdulwahab Al-Shamahy; Eshrak Adulmalik Al-gunaid; Ahmed Mohamed Al-Haddad

doi:10.22270/ujpr.v7i5.839

Mohammed Ismail Al-Mansor Medical Microbiology and Clinical Immunology Department, Faculty of Medicine and Health Sciences, Sana’a University.
Khaled Abdul-Karim A Al-Moyed Medical Microbiology and Clinical Immunology Department, Faculty of Medicine and Health Sciences, Sana’a University.
Mohammed Mohammed Al-Shehari General surgery Department, Faculty of Medicine and Health Sciences, Sana’a University.
Hassan Abdulwahab Al-Shamahy Medical Microbiology and Clinical Immunology Department, Faculty of Medicine and Health Sciences, Sana’a University. Medical Microbiology department, Faculty of Medicine, Genius University for Sciences and Technology, Dhamar city.
Eshrak Adulmalik Al-gunaid The National Center of Public Health Laboratories (NCPHL), Sana'a, Yemen.
Ahmed Mohamed Al-Haddad Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Hadhramout University, Republic of Yemen.

10.22270/ujpr.v7i5.839

Keywords:

Elevated titer antibody, Epstein-Barr virus, IgG EBV antibody, Systemic Lupus Erythematosus (SLE), Viral Capsid Antigen (VCA)

Abstract

Background and aims: Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease with damage to many organs due to the production of auto-antibodies, including auto-antibodies to renal antigen, vascular tissue antigens, brain antigens, ribosomes, nuclear antigens, and phospholipids. This study was conducted to determine patient characteristics and clinical manifestations of systemic lupus erythematosus and to find out the association of positive IgG with high titer of EBV-VCA with clinical features of SLE patients.

Materials and Methods: In this cross-sectional study, 142 patients with SLE diagnosed based on American College of Rheumatology criteria were selected. All were included in the study after obtaining informed consent for participation. Whole blood samples were taken and serum was separated to determine anti-EBV IgG antibodies using the ELISA method and assessment with the SLE.

Results: Female represent 81% of the total patients, while male represent only 19%, with ratio male: female equal to 1: 4.3, most of the patients were adults over 20 years old, with mean age ± SD was 35.8 ± 13.7 years. The most common signs were joint pain (95.1%), fever (92.3%), persistent fatigue (83.8%), followed by joint swelling (69.7%), photosensitivity (54.4%), renal involvement (52.8%), weigh loss (49.3%) and alopecia (49.3%), while other SLE signs were less frequent.

Conclusion: EBV may have an important role in SLE pathogenesis and activity, SLE male: female ratio equals 1:4.3, most patients were adults over 20 years of age, and the most common signs of SLE were joint pain, fever and persistent fatigue.

Peer Review History:

Received: 5 August 2022; Revised: 11 September; Accepted: 19 October; Available online: 15 November 2022

Academic Editor: Dr. Iman Muhammad Higazy, National Research Center, Egypt, imane.higazy@hotmail.com

Received file: Reviewer's Comments:

Average Peer review marks at initial stage: 5.5/10

Average Peer review marks at publication stage: 7.0/10

Reviewers:

Dr. Rima Benatoui,Laboratory of Applied Neuroendocrinology, Department of Biology, Faculty of Science, Badji Mokhtar University Annaba, Algeria. benattouiryma@gmail.com

Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com