HISTOPATHOLOGICAL FEATURES OF MICE LIVER AND KIDNEY ON ORAL ACUTE TESTING OF WHITE RADISH TUBER LYOPHILISATE

Abstract

Background and aim: Radish tuber (Raphanus sativus L.) is one of the plant species often consumed by society as a vegetable. Currently, its use is beginning to expand as a medicinal plant, including its use for diabetes, pharyngitis, sinusitis, cardiac fibrosis, diuretics, and bacterial infections. This study aims to determine the histopathology of the liver and kidney organs in male albino mice (Mus musculus) by testing the oral pungency of white radish (Raphanus sativus L.).

Methods: This experimental study used 12 mice weighing 25–30 grams, divided into 4 treatment groups: Group 1 was administered aquadest, Group 2 received a dose of 400 mg, Group 3 received 800 mg, and Group 4 received 1600 mg of the medication. The treatment was carried out for 14 days, and then the mice were euthanized to see the histopathology of the hepatic and kidney tissues.

Results: In the histopathology of the liver and kidney in treatment groups 1, 2, 3, and 4, the results were normal, mild, moderate, and severe damage, respectively. In kidney histopathology, there are signs of damaged tissue, such as bleeding, edema, and inflamation cells.

Conclusion: It can be concluded that the higher the dose of white radish lyophilizate, the greater the potential to cause toxicity to the liver and kidney organs.

                     

Peer Review History:

Received 3 December 2023;   Revised 29 January 2024; Accepted 27 February; Available online 15 March 2024

Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com

Average Peer review marks at initial stage: 6.0/10

Average Peer review marks at publication stage: 8.0/10

Reviewers:

Prof. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye

Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com