SYNTHESIS AND CHARACTERIZATION OF CEFADROXIL-BENZALDEHYDE DERIVED LIGAND, METAL COMPLEXES, AND EVALUATION OF THEIR ANTI-INFLAMMATORY, CYTOTOXIC, AND ANTIMICROBIAL ACTIVITIES

Md. Shahidul Islam; Samia Syda Nishat; Md. Rabiul Hossain; Rukyea Yeasmin Mysha; Rounak Jahan Israt; Md. Arif Ahmed

doi:10.22270/ujpr.v11i5.1668

Md. Shahidul Islam Department of Applied Chemistry and Chemical Technology, University of Science and Technology Chittagong, Bangladesh.
Samia Syda Nishat Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh.
Md. Rabiul Hossain Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh.
Rukyea Yeasmin Mysha Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh.
Rounak Jahan Israt Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh.
Md. Arif Ahmed Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh.

10.22270/ujpr.v11i5.1668

Keywords:

antibacterial, cefadroxil, NMR spectra, schiff base ligand, UV

Abstract

Background: The rise of infectious diseases and drug-resistant strains of bacteria and fungi poses a significant challenge, threatening human health and life expectancy. Researchers are actively working to develop novel antimicrobial therapies to counteract these issues.

Methods: In this study, new derivatives were synthesized from (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid (cefadroxil) by reaction with Benzaldehyde. The primary aim was to enhance the antibacterial efficacy of existing antibiotics and develop therapeutically active compounds. The synthesized ligand was characterized through elemental analysis, various physicochemical tests, and multiple spectroscopic techniques, including infrared (IR), ¹H NMR, ¹³C NMR, and UV spectroscopy. The ligand underwent solubility and chemical tests and was screened for in vitro antibacterial activity using the disc diffusion method. Anti-inflammatory and antioxidant properties were also evaluated.

Results: Synthesized compound exhibited superior antibacterial properties compared to cefadroxil alone, with significant zones of inhibition and MIC values. Additionally, anti-inflammatory and cytotoxicity tests yielded promising outcomes, indicating potential for future antibiotic applications.

Conclusion: Study concludes that while metal coordination with structural modifications could lead to the discovery of novel lead compounds with enhanced therapeutic potential.